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KMID : 0362720060440060359
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Journal of the Korean Dental Association
2006 Volume.44 No. 6 p.359 ~ p.366
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Evaluation on the bone regenerative capacity of deproteinized bovine
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Park Jun-Beom
Rhyu In-Chul
Kim Kyoung-Hwa
Lee Sang-Chul
Park Ho-Nam
Kim Tae-Il
Seol Yang-Jo
Lee Yong-Moo
Ku Young
Han Soo-Boo
Chung Chong-Pyoung
Han Sang-Hyuk
Park Yoon-Jeong
Lee Sang-Hoon
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Abstract
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Deproteinized bovine bone mineral has been widely used as graft material in maxillofacial and orthopedic areas. OCS-B짋(Nibec Inc.) is newly-developed inorganic bone mineral and the aim of the study is to evaluate the characteristics of OCS-B짋 as a bone graft substitute. OCS-B짋 was evaluated by scanning electron microscopy, energy dispersive X-ray spectrometer, Fourier transform-infrared spectrometer and Lowry protein analysis. and the regeneration potential. The regeneration potential of the graft was evaluated by creating calvarial defects in the rabbits and the alveolar defects in the beagle dogs. It was also inserted into femoral quadrant muscle in the mouse.
The result of this study indicated that OCS-B짋 displayed distinct surface properties and deproteinized bovine bone mineral showed relatively very small amount of residual protein. Osteoid was formed in the neighborhood of OCS-B짋 even at 2 weeks in the calvarial defects. The grafted area showed good ridge morphology and the osseous tissue showed numerous osteocytes, typical to the woven bone pattern in the beagle dogs. No inflammatory cells were seen on the surface OCS-B짋 at one and two weeks in the mouse.
It is concluded that newly-developed deproteinized bovine bone(OCS-B짋) is biocompatible material showing excellent regenerative potential.
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KEYWORD
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deproteinized bovine bone, bone formation, calvarial defect
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